Rumack-Matthew Nomogram

Name: Rumack-Matthew Nomogram
Creator: Daniel Diaz-Gil, MD
Keywords: Rumack-Matthew, acetaminophen, APAP, Tylenol, paracetamol, toxicity, nomogram, NAC, N-acetylcysteine, overdose, poisoning, hepatotoxicity

Acetaminophen toxicity assessment using the Rumack-Matthew nomogram to determine NAC treatment indication

Clinically Verified· 6 tests

For educational and informational purposes only. Verify all results before clinical application.

Serum Acetaminophen Level *

mcg/mL

Serum APAP concentration drawn at least 4 hours post-ingestion

Time Since Ingestion *

hours

Hours since single acute ingestion (nomogram valid 4-24 hours)

References

Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics. 1975;55(6):871-876.[DOI]
Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002;40(1):3-20.[DOI]

Reviewed by Daniel Diaz-Gil, MD · Last updated March 2026

Medical disclaimer

This tool is for educational and informational purposes only. It is not a substitute for professional clinical judgment. Always independently verify results before making clinical decisions.

Professional Resources — Tools used by pediatricians for toxicology assessment

Goldfrank's Toxicologic EmergenciesComprehensive toxicology reference for emergency management~$130via Amazon Antidote Reference CardQuick-reference card for common pediatric antidotes and dosing~$10via Amazon